Motif ID: RXR{A,B,G}.p2

Z-value: 1.701


Transcription factors associated with RXR{A,B,G}.p2:

Gene SymbolEntrez IDGene Name
RXRA 6256 retinoid X receptor, alpha
RXRB 6257 retinoid X receptor, beta
RXRG 6258 retinoid X receptor, gamma

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
RXRBchr6_-_33168438-0.495.1e-02Click!
RXRAchr9_+_1372183130.243.6e-01Click!
RXRGchr1_-_165414499-0.107.1e-01Click!


Activity profile for motif RXR{A,B,G}.p2.

activity profile for motif RXR{A,B,G}.p2


Sorted Z-values histogram for motif RXR{A,B,G}.p2

Sorted Z-values for motif RXR{A,B,G}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of RXR{A,B,G}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_2971281 3.073 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr6_-_2971787 2.877 SERPINB6
serpin peptidase inhibitor, clade B (ovalbumin), member 6
chr5_-_172755418 2.576 STC2
stanniocalcin 2
chr6_-_132272311 2.449 NM_001901
 CTGF
connective tissue growth factor
chr17_-_76921453 2.397 NM_003255
 TIMP2
TIMP metallopeptidase inhibitor 2
chr17_-_76921205 2.393 TIMP2
TIMP metallopeptidase inhibitor 2
chr11_-_86666211 2.392 NM_012193
 FZD4
frizzled family receptor 4
chr7_+_116166346 2.089 NM_001172896
NM_001172897
 CAV1

caveolin 1, caveolae protein, 22kDa

chr7_-_107643330 1.977 NM_002291
 LAMB1
laminin, beta 1
chr5_-_131563481 1.925 NM_001017974
NM_001142598
NM_001142599
 P4HA2


prolyl 4-hydroxylase, alpha polypeptide II


chr7_-_94285477 1.716 NM_001099400
NM_001099401
NM_003919
 SGCE


sarcoglycan, epsilon


chr21_+_46825001 1.678 NM_130445
 COL18A1
collagen, type XVIII, alpha 1
chr5_-_172755195 1.668 STC2
stanniocalcin 2
chr14_-_103988829 1.637 CKB
creatine kinase, brain
chr21_+_46825291 1.633


chr1_-_154946801 1.568 SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr1_-_154946859 1.554 NM_001130041
NM_001202859
NM_003029
 SHC1


SHC (Src homology 2 domain containing) transforming protein 1


chr7_-_94285426 1.478 SGCE
sarcoglycan, epsilon
chr7_-_94285372 1.462 SGCE
sarcoglycan, epsilon
chr3_-_120169493 1.430 NM_007085
 FSTL1
follistatin-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 28 entries
Enrichment   P-value GO Accession GO Term
17.96 3.51e-03 GO:0030198 extracellular matrix organization
17.55 3.92e-03 GO:0031589 cell-substrate adhesion
17.16 3.73e-02 GO:0030336 negative regulation of cell migration
17.16 3.73e-02 GO:2000146 negative regulation of cell motility
16.05 4.85e-02 GO:0051271 negative regulation of cellular component movement
11.71 2.80e-02 GO:0043062 extracellular structure organization
10.66 2.67e-04 GO:0001568 blood vessel development
9.94 4.56e-04 GO:0001944 vasculature development
8.11 3.78e-02 GO:0030334 regulation of cell migration
8.04 3.97e-02 GO:2000145 regulation of cell motility
7.04 1.56e-03 GO:0072358 cardiovascular system development
7.04 1.56e-03 GO:0072359 circulatory system development
5.42 3.83e-02 GO:0006928 cellular component movement
5.24 4.88e-02 GO:0009887 organ morphogenesis
4.84 4.02e-03 GO:0040011 locomotion
4.64 1.64e-02 GO:0009888 tissue development
4.58 1.81e-02 GO:0048699 generation of neurons
4.31 3.02e-02 GO:0022008 neurogenesis
3.54 4.89e-04 GO:0048513 organ development
3.48 1.78e-02 GO:0007399 nervous system development

Gene overrepresentation in compartment category:

Showing 1 to 9 of 9 entries
Enrichment   P-value GO Accession GO Term
56.11 3.90e-02 GO:0005583 fibrillar collagen
28.07 1.12e-02 GO:0005581 collagen
21.30 2.42e-03 GO:0005604 basement membrane
18.91 4.39e-05 GO:0044420 extracellular matrix part
8.84 7.79e-04 GO:0005578 proteinaceous extracellular matrix
8.36 2.54e-04 GO:0031012 extracellular matrix
5.18 1.02e-05 GO:0044421 extracellular region part
5.13 3.50e-04 GO:0005615 extracellular space
3.49 2.27e-04 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
Enrichment   P-value GO Accession GO Term
77.15 2.22e-02 GO:0008191 metalloendopeptidase inhibitor activity
77.15 2.22e-02 GO:0010576 metalloenzyme regulator activity
77.15 2.22e-02 GO:0048551 metalloenzyme inhibitor activity
68.58 2.85e-02 GO:0003706 ligand-regulated transcription factor activity
56.11 4.33e-02 GO:0048407 platelet-derived growth factor binding
22.71 1.85e-04 GO:0005201 extracellular matrix structural constituent
19.93 3.50e-03 GO:0005178 integrin binding
12.24 2.34e-02 GO:0019838 growth factor binding
10.94 3.59e-02 GO:0004866 endopeptidase inhibitor activity
10.81 6.92e-03 GO:0061134 peptidase regulator activity
10.75 3.84e-02 GO:0030414 peptidase inhibitor activity
10.48 4.23e-02 GO:0061135 endopeptidase regulator activity
7.34 1.11e-02 GO:0032403 protein complex binding
3.67 1.97e-02 GO:0005102 receptor binding